Solution Spotlight: Avatrombopag
Thrombocytopenia in CLD Patients
There are approximately 7.4MM patients in the United States with CLD. Given the nature of the disease, a common complication in this patient population is thrombocytopenia, a disorder characterized by platelet counts <150,000 per microliter of circulating blood, which affects approximately 1.1MM of these patients. Approximately 70,000 of these patients have what is known as severe thrombocytopenia, which occurs when platelet counts fall below 50,000 per microliter of circulating blood.
When these patients undergo a routine planned medical procedure such as a liver biopsy, colonoscopy, dental procedure, etc., which typically occurs 1-3 times a year, medical treatment guidelines recommend a platelet transfusion prior to the procedure in order to prevent the risk of bleeding during or after the procedure. These platelet transfusions are associated with both limitations and risks including antibody development risk, infection risk, and patient inconvenience.
There are currently no drug treatments approved by the U.S. Food & Drug Administration or the European Medicines Agency in this setting for this patient population.